Item Details
Gene/Locus name ITGA2 (also called CD49B, CD49b ) What are gene names?
Long Nameintegrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Edit date 04:11 PM, 17 Aug 2009
MBS listing No MBS Listing
Laboratories Australian and New Zealand laboratories providing this test can be found by clicking here.
Method
Reference sequence NM 002203
Application Variations in this gene/locus can be associated with following disorder/s:

Thrombocytopenia, neonatal alloimmune, posttransfusion purpura, included

Requestors should be aware that testing for inherited genetic variants often raises significant medical, ethical, psychological, and legal issues. Testing should be done in accordance with national guidelines which address clinical issues NHMRC and laboratory requirements NPAAC. Consultation with the genetics laboratory, a specialist clinician, or a clinical genetics service may be warranted.
Interpretation / Comment Laboratory methods do not necessarily identify all of the clinically significant variants in a gene. The failure to identify a variant does not necessarily mean that the gene is normal. Variants in a gene may cause more than one disease, and the identification of a clinically significant variant does not necessarily indicate the specific disease that the patient or relatives may be at risk of developing. Conversely, the disease/s associated with a gene might also be caused by mutations in other genes, and the failure to identify a clinically significant variant in one gene does not necessarily alter the clinical diagnosis or risk for relatives.
Reference OMIM 192974