Item Details
Gene/Locus name KRAS (also called KRAS2, KRAS1 ) What are gene names?
Long Namev-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Edit date 02:26 PM, 06 Sep 2016
MBS listing In some circumstances there is a Medicare rebate for testing this gene/locus; refer to Medicare for details. http://www9.health.gov.au/mbs/fullDisplay.cfm?type=item&q=73338&qt=item&criteria=KRAS
Laboratories Australian and New Zealand laboratories providing this test can be found by clicking here.
Method Laboratories may use a variety of methods to identify genetic variants. The sensitivity and specificity of these methods can vary, and some pathogenic variants in the gene may not be identified. The failure to identify a pathogenic variant may not necessarily mean that the gene is normal. Requestors should seek further advice from the laboratory.
Reference sequence NM_033360
Application Variations in this gene/locus can be associated with following disorder/s:

LEUKEMIA, ACUTE MYELOGENOUS , OMIM 601626
BREAST CANCER, SOMATIC, OMIM 114480
LUNG CANCER, OMIM 211980
STOMACH CANCER, OMIM 137215
BLADDER CANCER, OMIM 109800
PANCREATIC CARCINOMA, SOMATIC, OMIM 260350
COSTELLO SYNDROME, OMIM 218040
NOONAN SYNDROME 3, OMIM 609942

Requestors should be aware that testing for inherited genetic variants often raises significant medical, ethical, psychological, and legal issues. Testing should be done in accordance with national guidelines which address clinical issues NHMRC and laboratory requirements NPAAC. Consultation with the genetics laboratory, a specialist clinician, or a clinical genetics service may be warranted.
Interpretation / Comment Laboratory methods do not necessarily identify all of the clinically significant variants in a gene. The failure to identify a variant does not necessarily mean that the gene is normal. Variants in a gene may cause more than one disease, and the identification of a clinically significant variant does not necessarily indicate the specific disease that the patient or relatives may be at risk of developing. Conversely, the disease/s associated with a gene might also be caused by mutations in other genes, and the failure to identify a clinically significant variant in one gene does not necessarily alter the clinical diagnosis or risk for relatives.
Reference OMIM 190070